The Effect of Zinc on Content of Metallothionein and Ultrastructure in Liver and Brain of Rats Injected with Methylmercury

doi:10.3969/j.issn.1674-5817.2011.04.005

Abstract

Abstract: Objective To study the effect of zinc on metallothionein content and cell ultrastructural in liver and brain of rats treated with methylmercury. Methods The rats were randomly divided into four groups: zinc sulfate group, Zn sulfate+MeHg group, MeHg group and control group. The metallothionein (MT) contents and cell ultrastructure in liver and brain were examed. Results Zinc can enhance metallothionein content in the liver and brain of rats exposed to methylmercury. The result of live and brain cells ultrastructure of rats exposed to methylmercury also reveal that cell gap widened, dense mitochondria in the cytoplasm, ribosome increased, accompanied by swelling of the endoplasmic reticulum vacuolization, chromatin aggregation. In contrast, compared with the control group. the zinc sulfate + methylmercury group is no significant difference. Conclusion Zinc can inhibit the cell damage caused by methylmercury.

Key words: Zinc, Methylmercury, Metallthionein, Ultrastructure

CLC Number:

Q95-33

SHI Yong, WANG Zi-wei, SONG Xiang-fu, SUN Bing-xue. The Effect of Zinc on Content of Metallothionein and Ultrastructure in Liver and Brain of Rats Injected with Methylmercury[J]. Laboratory Animal and Comparative Medicine, 2011, 31(4): 252-254.

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