Laboratory Animal and Comparative Medicine ›› 2018, Vol. 38 ›› Issue (1): 78-82.DOI: 10.3969/j.issn.1674-5817.2018.01.017

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Research Progress in Animal Model of Cataract

JIA Jie, DAI Jie-jie   

  1. Center of Tree Shrew Germplasm Resources,Institute of Medical Biology,the Chinese Academy of Medical Science and Peking Union Medical College; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases; The Key Laboratory of Yunnan Province for Ophthalmic Research and Disease Control; Yunnan Innovation Team of Standardization and Application Research in Tree Shrew,Kunming 6500118,China
  • Received:2017-07-28 Online:2018-02-25 Published:2021-03-01

Abstract: This paper summarized the method for establishing animal models of congenital,traumatic,artificially induced and cellular-level cataract that have been studied at domestic and abroad in nearly resent 20 years.The characteristics,evaluation criteria and related mechanisms of each model were also described.The paper also proposesed a method for studying the expression of gene in lens cells that in different state of cataract by established immortalized lens cell lines,and an assumption that setting up tree shrew model for cataract that are similar to human cataract.

Key words: Cataracts, Animal models, Laboratory animal

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