Laboratory Animal and Comparative Medicine ›› 2012, Vol. 32 ›› Issue (6): 549-552.DOI: 10.3969/j.issn.1674-5817.2012.06.021

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Progress on Monitoring Methods of Oxidative Stress after Stress in Laboratory Animals

ZENG Xian-cheng1, MA Jing1, CHANG Yan1, LIU Quan-hai2   

  1. 1. National Shanghai Center for Drug Safety Evaluation and Research, 201203, China;
    2. Shanghai Institute of Pharmaceutical Industry, 201210, China
  • Received:2012-02-17 Online:2012-12-25 Published:2012-12-25

Abstract: Stress could induce oxidative stress in laboratory animals. Changes in energy metabolism in several aspects of the organism are one of the mechanisms through which the stress induces oxidative stress. Glucocorticoids take part in occurrence of oxidative stress after stress. Reactive oxygen species(ROS) levels, antioxidant capacity and contents of biomarkers of oxidative stress injury can be used to evaluate occurrence and damage of the oxidative stress. It was reviewed in this article that progress in the fields of how strees induce oxidative stress in laboratory animals, the mechanisms and the monitoring methods in recent years.

Key words: Stress, Oxidative stress, Laboratory animals

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