Prevention and Control of Pathogenic Microorganisms for the Management and Biosafety Control in Laboratory Animal Facilities

doi:10.12300/j.issn.1674-5817.2020.219

Abstract

Abstract: Appropriate biosafety management is a critical component of the successful operation of laboratory animal facilities. Standardizing the management of laboratory animal facilities, protecting staff, and strengthening the construction of laboratory animal health monitoring system are inevitable needs for the benign development of the laboratory animal industry. The control of microbial pathogens is a core component of laboratory biosafety management, and it is an important index for the evaluation of laboratory operation and management. The potential biosafety risk of animal laboratories is high owing to the experimentations with live animals, or pathogenic microorganisms. The control of microbial pathogens is an effective measure to reduce the risk of occupational exposure and acquired infections in laboratories. This study discusses microbial pathogen control strategies in laboratory animal facilities for promoting laboratory animal facility management and biosafety control.

Key words: Laboratory animal, Pathogenic microorganism, Facility management, Acquired infection, Occupational exposure, Biosafety

CLC Number:

Q95-33
R-332

LUO Yinzhu, Min Fangui, WANG Jing, HE Lifang, PAN Jinchun. Prevention and Control of Pathogenic Microorganisms for the Management and Biosafety Control in Laboratory Animal Facilities[J]. Laboratory Animal and Comparative Medicine, 2021, 41(5): 443-449.

Figures/Tables 5

References

[1] MCARTHUR D B.Emerging infectious diseases[J]. Nurs Clin N Am, 2019, 54(2):297-311. DOI:10.1016/j.cnur.2019.02.006.
[2] 卢胜明, 赵德明. 中国实验动物产业化发展现状及方向研究[J]. 实验动物科学, 2008, 25(4):33-44.
[3] 田克恭, 贺争鸣, 刘群. 实验动物疫病学[M]. 北京: 中国农业出版社, 2015.
[4] 陆兵, 刘秋焕, 王荣, 等. 结核分枝杆菌实验室获得性感染事件分析[J]. 中国防痨杂志, 2012, 34(5):333-335.
[5] KAWAMATA J, YAMANOUCHI T, DOHMAE K, et al.Control of laboratory acquired hemorrhagic fever with renal syndrome (HFRS) in Japan[J]. Lab Anim Sci, 1987, 37(4):431-436.
[6] VENTER M, STEYL J, HUMAN S, et al.Transmission of West Nile virus during horse autopsy[J]. Emerg Infect Dis, 2010, 16(3):573-575. DOI:10.3201/eid1603.091042.
[7] HSU CH, FARLAND J, WINTERS T, et al.Laboratory-acquired vaccinia virus infection in a recently immunized person—Massachusetts, 2013[J]. MMWR Morb Mortal Wkly Rep, 2015, 64(16):435-438.
[8] LU B, CUI L B, GU M H, et al.Outbreak of vaccinia virus infection from occupational exposure, China, 2017[J]. Emerg Infect Dis, 2019, 25(6):1192-1195. DOI:10.3201/eid2506.171306.
[9] 尹萍, 李志军. 实验室人员因动物实验感染流行性出血热九例[J]. 中华劳动卫生职业病杂志, 2007, 25(7):428-429. DOI:10.3760/cma.j.issn.1001-9391. 2007. 07.019.
[10] Center for Infectious Disease Research and Policy. Canadian lab worker released from Ebola quarantine[A/OL]. News Scan for Nov 29, 2016. http://www.cidrap.umn.edu/news-perspective/2016/11/news-scan-nov-29-2016.
[11] Ebola,lab accident death-Russia (Siberia): 20040522.1377[A/OL]. 2004-05-22. https://promedmail.org/promed-posts/?archiveid=20040522.1377&submit=Search.
[12] LIU X Y, XUE K N, RONG R, et al.Fault tree analysis: investigation of epidemic hemorrhagic fever infection acquired in animal laboratories in China[J]. Biomed Environ Sci, 2016, 29(9):690-695. DOI:10.3967/bes2016.093.
[13] PENG H S, BILAL M, IQBAL H.Improved biosafety and biosecurity measures and/or strategies to tackle laboratory-acquired infections and related risks[J]. Int J Environ Res Public Heal, 2018, 15(12):2697. DOI:10.3390/ijerph15122697.
[14] WURTZ N, PAPA A, HUKIC M, et al.Survey of laboratory-acquired infections around the world in biosafety level 3 and 4 laboratories[J]. Eur J Clin Microbiol Infect Dis, 2016, 35(8):1247-1258. DOI:10.1007/s10096-016-2657-1.
[15] 夏菡, 黄弋, 马海霞, 等. 美国高等级生物安全实验室人员培训体系及其启示[J]. 实验室研究与探索, 2019, 38(12):252-255. DOI:10.3969/j.issn.1006-7167. 2019. 12.058.
[16] 中国实验动物学会. 实验动物动物实验生物安全通用要求: T/CALAS7—2017[S].2017-05-18.
[17] 王静, 袁文, 闵凡贵, 等. 实验动物病原PCR检测方法系列团体标准的编制[J]. 中国比较医学杂志, 2019, 29(3):60-66.
[18] LUCHINS K R, BOWERS C J, MAILHIOT D, et al.Cost comparison of rodent soiled bedding sentinel and exhaust air dust health-monitoring programs[J]. J Am Assoc Lab Animal Sci, 2020, 59(5):508-511. DOI:10.30802/AALAS-JAALAS-20-000003.
[19] MAILHIOT D, OSTDIEK AM, LUCHINS KR, et al.Comparing mouse health monitoring between soiled-bedding sentinel and exhaust air dust surveillance programs[J]. J Am Assoc Lab Anim Sci, 2020, 59(1):58-66. DOI:10.30802/AALAS-JAALAS-19-000061.
[20] BUCHHEISTER S, BLEICH A.Health monitoring of laboratory rodent colonies—talking about (R)evolution[J]. Animals, 2021, 11(5):1410. DOI:10.3390/ani11051410.
[21] 刘艳, 王珑. 动物实验活动中病原微生物危害风险评估体系的建立[J]. 实验动物科学, 2015, 32(1):37-40. DOI:10.3969/j.issn.1006-6179.2015.01.009.
[22] 刘芳. 浅谈病原微生物实验室生物安全管理工作中风险评估的作用[J]. 中国卫生产业, 2017, 14(30):22-23. DOI:10.16659/j.cnki.1672-5654.2017.30.022.
[23] BAYOT ML, LIMAIEM F.Biosafety guidelines[M/OL]. Treasure Island (FL): StatPearls Publishing, 2021. https://pubmed.ncbi.nlm.nih.gov/30725895/
[24] 邵奇鸣, 窦木林. 实验动物设施的职业健康管理体系的建立与实施初探[J]. 中国比较医学杂志, 2018, 28(8):1-6.
[25] VONESCH N, TOMAO P, DI RENZI S, et al.Biosafety in laboratories concerning exposure to biological agents[J]. G Ital Med Lav Ergon, 2006, 28(4):444-456.
[26] 杜小燕, 王超, 陈振文. 兽医在实验动物工作中的主要作用[J]. 实验动物科学, 2012, 29(6):48-51.