量子点的急性毒性及动力学初步观察

doi:10.3969/j.issn.1674-5817.2011.04.006

实验动物与比较医学 ›› 2011, Vol. 31 ›› Issue (4): 255-258.DOI: 10.3969/j.issn.1674-5817.2011.04.006

量子点的急性毒性及动力学初步观察

孙鹏¹, 李鹏¹, 张旭瑞², 乔伟伟³, 赵霞⁴, 张云鹏¹

复旦大学1.附属华山医院普外科,上海 200040;
2.高分子科学系,上海 200433;
3.实验动物科学部,上海 200032;
4.附属华山医院耳鼻喉头颈外科,上海 200040

收稿日期:2010-12-10 出版日期:2011-08-25 发布日期:2011-08-25
作者简介:孙鹏(1968-), 男, 博士, 副教授, 专业方向: 普通外科, E-mail: indusrain@163.com;共同第一作者: 李鹏(1984-), 男, 汉族, 硕士研究生, 专业方向: 普通外科, E-mail: lipeng204@163.com
基金资助:
国家自然科学基金(No.20874015); 上海市科委纳米专项基金(No.1052nm03802)

Observations on Distribution of Quantum Dots and Acute Toxicity in Rats

SUN Peng¹, LI Peng¹, ZHANG Xu-rui², QIAO Wei-wei³, ZHAO Xia⁴, ZHANG Yun-peng¹

1. Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China;
2. Key Laboratory of Molecular Engineering of Polymers, Ministry of Education, Fudan University, Shanghai 200433, China;
3. Department of Laboratory Animal Science, Fudan University, Shanghai 200032, China;
4. Department of Otolaryngology Head and Neck Surgery, Huashan Hospital, Fudan University, Shanghai 200040,China

Received:2010-12-10 Online:2011-08-25 Published:2011-08-25

摘要/Abstract

摘要： 目的研究量子点在大鼠体内脏器分布规律及大鼠对量子点的急性毒性反应。方法取12只大鼠,6只右前肢皮下注射量子点,6只注射生理盐水对照。注射后饲养2周,记录一般状况,解剖观察器官有无异常。测试主要器官内镉元素含量,评价量子点在体内脏器分布规律。结果实验组和对照组大鼠比较,一般状况无明显不同和异常,没有表现出急性毒性反应。量子点主要分布于肝脏,肾脏和脾脏。结论量子点毒性与多种因素有关。

关键词: 量子点(Qdots), 急性毒性, 电感耦合等离子体质谱仪

Abstract: Objective To study the acute toxicity and the distribution of quantum dots in rats. Methods Six rats underwent quantum dots injection at the subcutaneous of upper limbs while the other six rats underwent physiological saline injection at the same sites. Two weeks observation and post-observation dissection were done on all of the twelve rats to confirm if there were any abnormities. The distribution of quantum dots was measured by inductively coupled plasma-mass spectrometry. Results No apparent toxicity was seen during two weeks' observation. The results of Cadmium assay showed that quantum dots mainly accumulated in the livers, spleens and kidneys of the rats. Conclusions The toxicity of quantum dots can be affected by many factors, which remain further research.

Key words: Quantum dots, Acute toxicity, Inductively coupled plasma-mass spectrometry

中图分类号:

Q95-33

孙鹏, 李鹏, 张旭瑞, 乔伟伟, 赵霞, 张云鹏. 量子点的急性毒性及动力学初步观察[J]. 实验动物与比较医学, 2011, 31(4): 255-258.

SUN Peng, LI Peng, ZHANG Xu-rui, QIAO Wei-wei, ZHAO Xia, ZHANG Yun-peng. Observations on Distribution of Quantum Dots and Acute Toxicity in Rats[J]. Laboratory Animal and Comparative Medicine, 2011, 31(4): 255-258.

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量子点的急性毒性及动力学初步观察

Observations on Distribution of Quantum Dots and Acute Toxicity in Rats

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