小鼠诺瓦克病毒研究现状

doi:10.3969/j.issn.1674-5817.2014.02.019

实验动物与比较医学 ›› 2014, Vol. 34 ›› Issue (2): 167-170.DOI: 10.3969/j.issn.1674-5817.2014.02.019

• 综述 • 上一篇

小鼠诺瓦克病毒研究现状

刘芹^1,2, 魏晓锋³, 高诚^2,3

1.复旦大学, 上海 200032;
2.上海市计划生育科学研究所, 上海 200032;
3.上海实验动物研究中心, 上海 201203

收稿日期:2013-10-18 出版日期:2014-04-25 发布日期:2014-04-25
作者简介:刘芹(1987-), 女, 硕士, 研究方向: 实验动物质量控制。E-mail: liuqin870101@126.com
基金资助:
上海市科委创新行动计划“小鼠诺瓦克病毒的特性研究”(NO.12140900502)

Situation on Research of Murine Norovirus

LIU Qin^1,2, WEI Xiao-feng³, GAO Cheng^2,3

1. Fudan University, Shanghai 200032, China;
2. Shanghai Institute of Planned Parenthood esearch, Shanghai 200032, China;
3. Shanghai Laboratory Animal Research Center, Shanghai 201203, China

Received:2013-10-18 Online:2014-04-25 Published:2014-04-25

摘要/Abstract

摘要： 诺瓦克病毒(Norwalk virus, NV), 也称为诺如病毒(norovirus, NV),是引起人类非细菌性胃肠炎的主要病原体,此外,在牛、猪和小鼠也发现了诺瓦克病毒的存在。该病毒可分5个基因型(GI~V),鼠诺瓦克病毒(Murine norovirus, MNV)属于GV,是一种新发现的感染实验小鼠的病毒,并且被认为是目前小鼠中最流行的一种病毒。MNV是诺瓦克病毒中在细胞内有效复制的病毒,被作为研究诺瓦克病毒复制分子机制的模型,同时 MNV与人诺瓦克病毒(Human noroviruses,HuNV)有许多相似的分子生物学特点,也被认为是研究人诺瓦克病毒的理想病毒模型。

关键词: 小鼠诺瓦克病毒(MNV), 生物学特点, 流行病学

Abstract: Norwalk virus, also known as norovirus, is the major pathogen to cause human nonbacterial gastroenteritis, in addition, Norwalk virus is also found in cattle, pigs and mice . Norwalk virus can be divided into five genotypes (GI-V), and the murine norovirus (MNV) belongs to GV. MNV is a newly discovered virus infection in laboratory mice, and is considered to be the most popular form of mouse virus. Now, MNV is the only one that can be replicated efficiently in cells of the Norwalk virus, so MNV is regarded as a research model for the molecular mechanism of Norwalk virus. Moreover, MNV and human Norovirus (HuNV) have many similar characteristics of molecular biology, and also is considered to be the ideal virus model for study of human norovirus.

Key words: Murine norovirus(MNV), Biological characteristics, Epidemiology

中图分类号:

Q95-33

刘芹, 魏晓锋, 高诚. 小鼠诺瓦克病毒研究现状[J]. 实验动物与比较医学, 2014, 34(2): 167-170.

LIU Qin, WEI Xiao-feng, GAO Cheng. Situation on Research of Murine Norovirus[J]. Laboratory Animal and Comparative Medicine, 2014, 34(2): 167-170.

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小鼠诺瓦克病毒研究现状

Situation on Research of Murine Norovirus

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