妊娠中期SD大鼠压力反射敏感性的变化

›› 2008, Vol. 28 ›› Issue (6): 390-393.

妊娠中期SD大鼠压力反射敏感性的变化

1.复旦大学附属妇产科医院，上海 200011；2.复旦大学上海医学院，上海 200032；3.复旦大学实验动物科学部，上海 200032

收稿日期:2008-06-05 出版日期:2008-06-30 发布日期:2008-06-30
基金资助:
上海市科委重点项目资助（064909006）

Changes in Baroreflex Sensitivity in Middle Pregnant SD Rats

1. Obstetrics & Gynecology Hospital of Fudan University, Shanghai 200011, China; 2. Department of Physiology & Pathophysiology, Shanghai Medical College of Fudan University, Shanghai 200032,China; 3. Department of Laboratory Animal Science, Fudan University, Shanghai 200032, China

Received:2008-06-05 Online:2008-06-30 Published:2008-06-30

摘要/Abstract

摘要： 目的研究妊娠中期SD大鼠心率变异性（HRV）、血压变异性（BPV）和压力反射敏感性（BRS）的变化。方法在清醒、自由活动状态下测定妊娠SD大鼠和正常对照SD大鼠的HRV、BPV和自发性BRS；静脉注射去氧肾上腺素（5μg/kg）以测定压力反射对心率的控制功能（BRS_HR）。结果妊娠大鼠与正常对照大鼠相比HRV高频成分降低，自发性BRS降低（P＜0.05）。结论妊娠中期SD大鼠的迷走神经调节功能下降，压力反射敏感性降低。频谱分析的方法测定自发性压力反射敏感性是可靠的方法。

关键词: 心率变异性, 血压变异性, 压力反射敏感性

Abstract: Objective To determine the changes of cardiovascular autonomic control in unrestrained conscious pregnant SD rats. Method Blood pressure, heart rate and their variabilities were measured in conscious, unstrained rats and middle pregnant rats. BRS of heart rate control(BRSHR) was measured by using a bolus intravenous injection of phenylephrine(5 jug/kg). Results HF of HRV as well as spontaneous BRS and BRShr attenuated (P<0.05) in pregnant SD rats compared with control group. Conclusion BRS reduced and regulating function of vagus decreased in middle pregnant SD rats. Measurement of HRV, BPV and BRS by spectral analysis is credible.

Key words: Baroreflex sensitivity, Heart rate variability, Blood pressure variability

沈婕1，丰有吉1，沈霖霖2，乔伟伟3，李笑天1. 妊娠中期SD大鼠压力反射敏感性的变化[J]. , 2008, 28(6): 390-393.

SHEN Jie1，FENG You-ji1, SHEN Lm-lm2, QIAO Wei-wei3，LI Xiao-tian1 . Changes in Baroreflex Sensitivity in Middle Pregnant SD Rats[J]. , 2008, 28(6): 390-393.

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