关键词: 辐射, 骨髓移植, 卵巢损伤修复, 小鼠

Abstract: Objectives To evaluate the effect of radiotherapic ovary recovery function by bone marrow transplantation and discuss the possible mechanisms. Methods One humdred female Kunming mice,at the age of 6?10 weeks were used，20 of them were selected as donor for bone marrow transplantation, 40 of them were selected as control group after once radiotherapy, 40 of them were selected as experimental group，processed transplantation 48 h after radiotherapy. On day 1st, 5th, 15th, 30th, the E₂, FSH level of these mouse were detected and the morphological changes of impaired ovary observed were. Results On day 15th and 30th，compared with control group, the experimental group presented more primordial follicle, primary oocytes，mature oocytes than control group, and showed less accrementition and hyalinization in ovarian vessel. The E₂ and FSH of control group was maintain at 18 ng/L and 3 IU/L，while the E₂ in experimental group was up to 24.69 ng/L, FSH level dropped to 2.14 mlU/ml. Conclusions The experimental group resumed generating new oocytes and follicles，the bone marrow transplantation may have recovery function to radiotherapic impaired ovary.

Key words: Radiotherapy, Bone marrow therapy, Recovery of impaired ovary, Mouse