猪诱导室颤复苏后运用超声心动图评价心脏功能

实验动物与比较医学 ›› 2008, Vol. 28 ›› Issue (1): 10-13.

猪诱导室颤复苏后运用超声心动图评价心脏功能

1.苏州大学附属第一医院心内科，苏州 215006；2.苏州大学实验动物中心，苏州 215006

收稿日期:2007-06-27 出版日期:2008-01-31 发布日期:2008-01-31

The Valuation of Postresuscitation Myocardial Function after Ventricular Fibrillation by Echocardiography

l.The First Hospital Affiliated to Suzhou University, Suzhou 215006，China;2.The Laboratory Animal Research Center, Suzhou University, Suzhou 215006,China

Received:2007-06-27 Published:2008-01-31 Online:2008-01-31

摘要/Abstract

摘要： 目的探讨猪在人工诱发心室颤动复苏后心脏功能的变化情况.方法采用置右心室电极诱导太湖猪发生室颤，然后行经胸体外电除颤，并通过超声心动图评价复苏成功后不同时间段太湖猪心功能状况.结果二个实验组猪在复苏成功后心功能均降低，室颤6min组心功能降低与同组基础状态和室颤 2min 组均有显著性差异.至 72h 时恢复至与基础状态无差异.结论随着室颤时间的延长，复苏成功后出现的心功能障碍越重.这种心功能障碍可能是一种伴左心室扩张的可逆性心功能不全.

关键词: 太湖猪, 室颤, 电除颤, 超声心动图

Abstract: Objective To investigate the functional changes in the myocardium afler successful resuscitation from ventricular fibrillation(VF). Methods Ventricular fibrillation was induced in Taihu-pigs with an alternating current(AC) delivered to the right ventricular endocardium. Afler either 2 or 6 minutes of untreated ventricular fibrillation,the animals were attempted to defibrillate. Then transthoracic echocardiography was applied to evaluate myocardial function after successful resuscitation. Results Myocardial dysfunction of all animals after successful resuscitation were observed,which had remarkable improvement when they survived more than 72 hours. Myocardial function of the animals afler 6 min of untreated ventricular fibrillation had more serious impairment than that after 2 minutes(P＜0.05). Conclusion As the duration of untreated ventricular fibrillation was prolonged,the severity of postresuscitation myocardial dysfunction would be increased. The myocardial dysfunction with left ventricle dilation may be reversible probably.

Key words: Taihu-Pig, Ventricular fibrillation, Defibrillation, Echocardiography

李松华1,杨俊华1,王禹斌2,等. 猪诱导室颤复苏后运用超声心动图评价心脏功能[J]. 实验动物与比较医学, 2008, 28(1): 10-13.

LI Song-Hua-1,YANG Jun-Hua-1,WANG Yu-Bin-2,et al. The Valuation of Postresuscitation Myocardial Function after Ventricular Fibrillation by Echocardiography[J]. Laboratory Animal and Comparative Medicine, 2008, 28(1): 10-13.

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