关键词: 冠心宁片, 老年大鼠, 血液流变学, 活血化瘀

Abstract: Objective To observe the effect of Guanxinning tablet on hemorrheology and correlative biochemical indexes in aged rats. Methods Fifty 15-month-old male SD rats were randomly divided into 5 groups including a model control group, a positive control group and low （0.3g·kg^-1）, middle （0.6g·kg^-1） and high （1.2 g·kg^-1） dose groups of Guanxinning tablet. An additional ten 3-month-old rats were used as the normal control group. Determine the hemorrheology and the biochemical indexes of glucose （GLU）, total cholesterol （TC）, triglyeride （TG）, superoxide dismutase （SOD） and malondialdehyde （MDA） in blood serum of rats after 15 days. Results Guanxinning tablet with low, middle and high dose had significant depressed effect on the level of blood viscosity, plasma viscosity, erythrocyte rigidity index, and significant elevated effect on the activity of SOD and depressed effect on the content of MDA in serum of aged rats. Guanxinning tablet with high dose had significant depressed effect on the level of TC and GLU. Conclusion Guanxinning tablet had significant amendatory effect on the abnormity of blood viscosity and erythrocyte rheological characteristic in aged rats, and contributed to inhibit the peroxidation of free radical, protect the activity of anti-oxidative enzyme, boost elimination ability for free radical. In a word, Guanxinning tablet had the characteristic of promoting blood circulation by removing blood stasis.

Key words: Guanxinning tablet, Aged rats, Hemorrheology, Stimulate circulation to end stasis