Abstract: Objective To detect the activity of PLA₂ and the content of PGE₂ at local chronic compression injury in rat spinal cord. Methods Biochemical activity method was used to detect the activity of PLA₂. Radio-immunity method was used to detect the content of PGE₂ . Results （1） The activity of PLA₂： The activity of PLA₂ in experimental groups was increased after spinal cord compression, especial in the moderate compression group. There was significant difference （P＜0.01） of the activity of PLA₂ between the moderate compression group and the Sham-operated group. There also existed significant different （P＜0.05） of the activity of PLA₂ between severe, medium compression group and Sham-operated group.（2）The content ofPGE_{2P＜0.01） of the activity ofPGE2P＜0.05） of the activity ofPGE2P＜0.05） of the activity ofPGE2}