关键词: 变应性鼻炎, 动物模型

Abstract: Objective To establish a useful experimental system for evaluating the effect of drugs on allergic rhinitis. Method An animal disease model of allergic rhinitis was developed with Brown Norway rat and Sprague-Dawley rat, immunized with ovalbumin（OVA） emulsified in Al（OH）3 adjuvant. The nasal vascular permeability was assessed by determining the extent of the Evan’blue released into the nasal perfusate following the OVA challenge to the nasal cavity of rats. Results The release of Evan’blue following perfusion significantly increased in the sensitized BN rats and the released extent of Evan’blue was lower in the sham-sensitized BN rats. But there was no same result in SD rats. Conclusion The vascular permeability is accelerated by the immunized antigen of OVA in the sensitized BN rats and differs from that of sham-sensitized BN rats. Measurement of the extent of nasal vascular permeability in allergic rhinitis model can be considered as a useful experimental system for evaluating drug effects on allergic rhinitis. BN rat are more sufficient than SD rat in this experiment.

Key words: Allergic rhinitis, Animal model