›› 2003, Vol. 23 ›› Issue (1): 7-9.
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国家自然科学基金资助项目(批准号30070910)
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摘要： 通过口腔滴注表皮生长因子（EGF），观察小鼠舌上皮细胞生长和表皮生长因子受体（EGF-R）的表达，研究EGF影响舌苔形成的分子机制。舌组织经HE染色、EGF-R SABC免疫组化染色和图像分析数据处理系统（CMIAS-98A多功能图象分析仪）进行分析。结果表明，EGF可能通过EGF-R机制进行信号传导促进小鼠舌上皮细胞增生、舌粘膜增厚、EGF-R表达增多。
关键词: 表皮生长因子, 舌苔, 免疫组化, 图象分析, 信号传导分子机制
Abstract: To research the signal mechanism between epidermal growth factor （EGF） and tongue-coating formation，the mice tongue mucosa cell growth with EGF-R expression was observed after droping EGF to mice mouth cavity.HE、EGF-R immuno-histochemistry （SABC） and by data handles system （CMIAS-98A） to proceed the image analysis were used. The results showed that EGF promotes the thickening of tongue mucosa in experiment mice，and the base layer cells and the EGF-R expression of tongue mucosa were increased.The EGF might influence the tongue-coating formation by the signal conduct mechanism of EGF-R.
Key words: Epidermal growth factor, Tongue-coating, Immunohistochemistry, Image analysis, Signal conduct mechanism
詹瑧，侯亮. 表皮生长因子影响小鼠舌苔形成的信号传导分子机制初探[J]. , 2003, 23(1): 7-9.
ZHAN Zhen, HOU Liang. Influence of Epidermal Growth Factor on Signal Conduct Mechanism of the Tongue-coating Formation in mice[J]. , 2003, 23(1): 7-9.
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