Abstract: To establish an allergic rhinitis model induced by Ascaris lumbricoides allergen,the guinea pigs（n= 30） were divided into a sensitized group（n=20） and an unsen-sitized control group（n=10）.Sensitized groups were immunized intraperitoneally and intracutaneously with Ascaris Imnbricoides allergen for 4 weeks，followed by intranasal administration. Unsensitized control group were treated with 0.9% NaCl instead of As-caris lumbricoides allergen. As a results，the symptoms of allergic rhinitis，such as sneezing，itching and rhinorrhea were observed in 18 guinea pigs of sensitized groups with significant increase in the number of eosinophils and mast cell in the epithelium after 30 min. The results suggested that the successfully established animal model of aller-gic rhinitis may be used as a tool for the study and treatment of allergic rhinitis,especial-ly induced by Ascaris lumbricoides allergen.