Abstract: To investigate the changes of blood lipid and intima at different time point after atherosclerosis of iliac artery in rabbits.The New Zealand White rabbits were divided randomly into normal diet group （n=7） and hypercholesterol diet group （n=28）. The atherosclerotic lesions were developed by inducing endothelial denudation with bal-loon catheter and being given high dosage of cholesterol diet at the same time. The artery blood were sampled and iliac arteries were removed at 1，2，4，8 weeks after en-dothelial injury respectively. The results showed that the level of TC，TG，LDL-C and intimal thickness，intima/media（I/M）increased continually with the time.Coefficient of linear correlation between intimal thickness and TC、TG、LDL-C were 0. 8981、0. 8793 and 0. 8682 （P＜0.01） respectively. The results suggested that clinic character of the process of atherosclerosis in the animal model was similar to that in human.