七甲川菁类化合物在肿瘤模型活体成像研究中的应用

doi:10.3969/j.issn.1674-5817.2019.05.001

摘要/Abstract

摘要： 七甲川菁类化合物不仅具有近红外荧光(near-infrared fluorescence, NIRF)染料特征,而且具有肿瘤靶向性,不需要化学修饰,可直接被肿瘤细胞吸收,呈特异性聚集,从而可用于肿瘤模型活体成像。该染料在人体肿瘤细胞系移植(cell-derived xenograft, CDX)模型、临床人源肿瘤组织异种移植(patient-derived tumor xenograft, PDX)模型和犬自发肿瘤模型中均显示出良好的特异性。其肿瘤靶向性由特异性有机阴离子转运肽(organic anion transporting peptides, OATP)调控,并受到低氧条件控制,这些特性将会拓展NIRF染料在肿瘤成像研究中的应用。

关键词: 近红外荧光(NIRF), 七甲川菁染料, 肿瘤靶向性, 活体成像, 有机阴离子转运肽

中图分类号:

Q95-33

师长宏. 七甲川菁类化合物在肿瘤模型活体成像研究中的应用[J]. 实验动物与比较医学, 2019, 39(5): 337-341.

参考文献

[1] Usama SM, Zhao B, Burgess K.A near-IR fluorescent dasatinib derivative that localizes in cancer cells[J]. Bioconjug Chem, 2019, 30(4):1175-1181.
[2] 赖漪娆, 丁晔伟, 施琳俊, 等. 近红外荧光成像在头颈部鳞癌手术治疗中的应用[J]. 临床口腔医学杂志, 2018, 34(8):506-509.
[3] 张贺, 张彩勤, 赵勇, 等. 基于临床手术标本的胰腺癌原位移植模型建立及评价[J]. 中国实验动物学报, 2018, 26(3):296-301.
[4] Liberale G, Vankerckhove S, Galdon MG, et al.Fluorescence imaging after intraoperative intravenous injection of indocyanine green for detection of lymph node metastases in colorectal cancer[J]. Eur J Surg Oncol, 2015, 41(9):1256-1260.
[5] Feng L, Yang Y, Huo X, et al.Highly selective NIR probe for intestinal β-glucuronidase and high-throughput screening inhibitors to therapy intestinal damage[J]. ACS Sens, 2018, 3(9):1727-1734.
[6] Yang JA, Kong WH, Sung DK, et al.Hyaluronic acid-tumor necrosis factor-related apoptosis-inducing ligand conjugate for targeted treatment of liver fibrosis[J]. Acta Biomater, 2015, 12:174-182.
[7] Keereweer S, Mol IM, Kerrebijn JD, et al.Targeting integrins and enhanced permeability and retention (EPR) effect for optical imaging of oral cancer[J]. J Surg Oncol, 2012, 105(7):714-718.
[8] Xu M, Rettig MP, Sudlow G, et al.Preclinical evaluation of Mab CC188 for ovarian cancer imaging[J]. Int J Cancer, 2012, 131(6):1351-1359.
[9] Tsuchimochi M, Yamaguchi H, Hayama K, et al. Imaging of metastatic cancer cells in sentinel lymph nodes using affibody probes and possibility of a theranostic approach[J]. Int J Mol Sci, 2019,20(2): pii: E427.
[10] Yi X, Yan F, Wang F, et al.IR-780 dye for near-infrared fluorescence imaging in prostate cancer[J]. Med Sci Monit, 2015, 21:511-517.
[11] Shao C, Liao CP, Hu P, et al.Detection of live circulating tumor cells by a class of near-infrared heptamethine carbocyanine dyes in patients with localized and metastatic prostate cancer[J]. PLoS One, 2014, 9(2):e88967.
[12] Yi X, Wang F, Qin W, et al.Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field[J]. Int J Nanomedicine, 2014, 9:1347-1365.
[13] Thomas RG, Moon MJ, Surendran SP, et al.MHI-148 cyanine dye conjugated chitosan nanomicelle with NIR light-trigger release property as cancer targeting theranostic agent[J]. Mol Imaging Biol, 2018, 20(4):533-543.
[14] Yang X, Shi C, Tong R, et al.Near IR heptamethine cyanine dye-mediated cancer imaging[J]. Clin Cancer Res, 2010, 16(10):2833-2844.
[15] Shi C, Wu JB, Pan D.Review on near-infrared heptamethine cyanine dyes as theranostic agents for tumor imaging, targeting, and photodynamic therapy[J]. J Biomed Opt, 2016, 21(5):50901-50911.
[16] Miranda D, Huang H, Kang H, et al.Highly-soluble cyanine J-aggregates entrapped by liposomes for in vivo optical imaging around 930 nm[J]. Theranostics, 2019, 9(2):381-390.
[17] Zhao N, Zhang C, Zhao Y, et al.Optical imaging of gastric cancer with near-infrared heptamethine carbocyanine fluorescence dyes[J]. Oncotarget, 2016, 7(35):57277-57289.
[18] Zhang C, Zhao Y, Zhang H, et al. The application of heptamethine cyanine dye HC and indocyanine green for imaging and targeting in xenograft models of hepatocellular carcinoma[J]. Int J Mol Sci, 2017, 18(6):pii:E1332.
[19] van der Vorst JR, Schaafsma BE, Verbeek FP, et al. Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients[J]. Oral Oncol, 2013, 49(1):15-19.
[20] Shi C, Wu JB, Chu GC, et al.Heptamethine carbocyanine dye-mediated near-infrared imaging of canine and human cancers through the HIF1α/OATPs signaling axis[J]. Oncotarget, 2014, 5(20):10114-10126.
[21] Wu JB, Shi C, Chu GC, et al.Near-infrared fluorescence heptamethine carbocyanine dyes mediate imaging and targeted drug delivery for human brain tumor[J]. Biomaterials, 2015, 67:1-10.
[22] An J, Zhao N, Zhang C, et al.Heptamethine carbocyanine DZ-1 dye for near-infrared fluorescence imaging of hepatocellular carcinoma[J]. Oncotarget, 2017, 8(34):56880-56892.
[23] Kim JS, Kim YH, Kim JH, et al.Development and in vivo imaging of a PET/MRI nanoprobe with enhanced NIR fluorescence by dye encapsulation[J]. Nanomedicine(Lond), 2012, 7(2):219-229.
[24] Wu J, Pan D, Chung LW.Near-infrared fluorescence and nuclear imaging and targeting of prostate cancer[J]. Transl Androl Urol, 2013, 2(3):254-264.
[25] Lutje S, Rijpkema M, Goldenberg DM, et al.Pretargeted dual-modality immuno-SPECT and near-infrared fluorescence imaging for image-guided surgery of prostate cancer[J]. Cancer Res, 2014, 74(21):6216-6223.
[26] Zhang Y, Xiao L, Popovic K, et al.Novel cancer-targeting SPECT/NIRF dual-modality imaging probe (99m)Tc-PC-1007: synthesis and biological evaluation[J]. Bioorg Med Chem Lett, 2013, 23(23):6350-6354.
[27] Wu JB, Shao C, Li X, et al.Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1alpha/OATPs signaling axis[J]. Biomaterials, 2014, 35(28):8175-8185.
[28] Hirche C, Murawa D, Mohr Z, et al.ICG fluorescence-guided sentinel node biopsy for axillary nodal staging in breast cancer[J]. Breast Cancer Res Treat, 2010, 121(2): 373-378.
[29] Hagenbuch B, Stieger B.The SLCO (former SLC21) superfamily of transporters[J]. Mol Aspects Med, 2013, 34(2-3):396-412.
[30] Liu T, Li Q.Organic anion-transporting polypeptides: a novel approach for cancer therapy[J]. J Drug Target, 2014, 22(1):14-22.
[31] Yuan J, Yi X, Yan F, et al.Nearinfrared fluorescence imaging of prostate cancer using heptamethine carbocyanine dyes[J]. Mol Med Rep, 2015, 11(2):821-828.
[32] Wang Y, Liu T, Zhang E, et al.Preferential accumulation of the near infrared heptamethine dye IR-780 in the mitochondria of drug-resistant lung cancer cells[J]. Biomaterials, 2014, 35(13):4116-4124.