Abstract: Objective To explore the methods of breeding and feeding of naked mole rat. Methods The pregnancy rate, fetal interval, litter size, number of weaning and survival of naked mole rat with the generation of full-sib mating were studied under suitable feeding and management condition. Results Naked mole rat can be adapt in an artificial environment through seven pairs of naked mole rat breeding. Female naked mole rats were caged with males at 8-12 months of age. The rate of first pregnancy was 71.43%. The litter size of first-born of five female naked mole rats was 9.20±3.90. The weaning rate was 7.60±5.03 with survival rate 75.10%±42.49%. The second births have totally 5 litters with the birth interval 89.00±19.53 days and litter size 9.60±5.68. The weaning rate was 6.20±4.09 with survival rate 74.33%±34.19%. The third births have totally 5 litters with the birth interval 99.60±17.17 days and litter size 12.40±4.77. The weaning rate was 10.00±3.08 with survival rate 82.91%±16.70%. Conclusion It was possible to establish the conventional naked mole-rat in laboratory.

Key words: Naked mole rat, Artificial environment, Feeding, Breeding