Experimental Operations Induced Stress in Rodents

doi:10.3969/j.issn.1674-5817.2014.03.018

Abstract

Abstract: The routine experimental operations ,such as handling, orogastric gavage, anaesthesia, blood collection, restrict, transport, etc . can induce stress in animals. The operations impact on some parameters correlated with stress and metabolic, which have a probable influence on experiment results. However, the impacts are usually ignored by researchers due to the pervasiveness of the operations. This article described the impacts respectively.

Key words: Experimental operations, Rodent, Stress

CLC Number:

Q95-33

WEI Shan-shan, YANG he-jin, QU Huihua, ZHAO Yan, WANG Qing-guo. Experimental Operations Induced Stress in Rodents[J]. Laboratory Animal and Comparative Medicine, 2014, 34(3): 255-258.

References

[1] Balcombe J P, Barnard N D, Sandusky C.Laboratory routines cause animal stress[J].Lab Anim Sci, 2004, 43(6):42-51.
[2] Eshkevari L, Permaul E, Mulroney SE.Acupuncture blocks cold stress-induced increases in the hypothalamic-pituitary-adrenal axis in the rat[J]. J Endocrinol, 2013, 217, 95-104.
[3] 李婧, 孙建栋, 刘岩, 等. 米非司酮对抑郁模型大鼠学习记忆能力的干预作用[J]. 药学学报, 2013, 48(8):1221-1226.
[4] Zhou D, Jin H, Lin H B, et al.Antidepressant effect of the extracts from Fructus Akebiae[J].Pharmacol Biochem Be, 2010, 94(3):488-495.
[5] 蒋春雷, 路长林. 应激医学[M]. 上海: 上海科学技术出版社, 2006.
[6] Sharp J, Zammit T, Azar T, et al.Stress-like responses to common procedures in individually and group-housed female rats[J].Lab Anim Sci, 2003, 42(1):9-18.
[7] Duke JL, Zammit TG, Lawson DM.The effects of routine cage-changing on cardiovascular and behavioral parameters in male Sprague-Dawley rats[J].Lab Anim Sci, 2001, 40(1): 17-20.
[8] De Boer SF, Koopmans SJ, Slangen JL, et al.Plasma catecholamine, corticosterone and glucose responses to repeated stress in rats: effect of interstressor interval length[J]. Physiol Behav, 1990, 47(6):1117-1124.
[9] Armario A, Montero JL, Balasch J.Sensitivity of corticosterone and some metabolic variables to graded levels of low intensity stresses in adult male rats[J]. Physiol Behav, 1986, 37(4): 559-561.
[10] Irwin J, Ahluwalia P, Zacharko RM, et al.Central norepinephrine and plasma corticosterone following acute and chronic stressors: influence of social isolation and handling[J]. Pharmacol Biochem Be, 1986, 24(4):1151-1154.
[11] Jacobsen KR, Kalliokoski O, Teilmann AC, et al.The effect of isoflurane anaesthesia and vasectomy on circulating corticosterone and ACTH in BALB/c mice[J]. Gen Comp Endocr, 2012:406-413.
[12] Arnold M, Langhans W.Effects of anesthesia and blood sampling techniques on plasma metabolites and corticosterone in the rat[J]. Physiol Behav, 2010, 99(5):592-598.
[13] Dispersyn G, Sage D, Challet E, et al.Plasma corticosterone in rats is specifically increased at recovery from propofol anesthesia without concomitant rise of plasma ACTH[J]. Chronobiol Int, 2009, 26(4):697-708.
[14] Kushikata T, Hirota K, Kotani N, et al.Isoflurane increases norepinephrine release in the rat preoptic area and the posterior hypothalamus in vivo and in vitro: Relevance to thermoregulation during anesthesia[J]. Neuroscience, 2005, 131(1):79-86.
[15] Johansen O, Vaaler S, Jorde R, et al.Increased plasma glucose levels after Hypnorm? anaesthesia, but not after Pentobarbital? anaesthesia in rats[J]. Lab Anim, 1994, 28(3): 244-248.
[16] 屈晓鹏, 李江, 高国栋. 吗啡自身给药大鼠复燃后药物戒断期的抑郁模型评估[J]. 中华神经外科疾病研究杂志, 2013, 12(3):218-221.
[17] 胡玉红, 潘震寰. 大鼠颈动脉及颈静脉置管方法[J]. 中国实验动物学杂志, 2000, 10(4):250-252.
[18] Frank P, Schoenhard GL, Burton E.A method for rapid and frequent blood collection from the rat tail vein[J]. J Pharmacol Meth, 1991, 26(3):233-238.
[19] Tsukamoto H, Reidelberger RD, French SW, et al.Long-term cannulation model for blood sampling and intragastric infusion in the rat[J]. Am J Physiol-Reg I, 1984, 247(3):R595-R599.
[20] 魏秀岩, 杨静玉, 吴春福. 黄芩苷对孤养小鼠的抗焦虑作用[J]. 沈阳药科大学学报, 2010 (2):142-146.
[21] 周利飞, 何静静, 胡意员, 等. 生命早期孤养对小鼠应激易感性的影响[J]. 温州医学院学报, 2013, 43(1):34-37.
[22] Vahl TP, Ulrich-Lai YM, Ostrander MM, et al.Comparative analysis of ACTH and corticosterone sampling methods in rats[J]. Am J Physiol-Endoc M, 2005, 289(5): E823-E828.
[23] Haemisch A, Guerra G, Furkert J.Adaptation of corticosterone-but not beta-endorphin-secretion to repeated blood sampling in rats[J]. Lab Anim Sci, 1999, 33:185-191.
[24] Garcia A, Marti O, Valles A, et al.Recovery of the hypothalamic-pituitary-adrenal response to stress[J]. Neuroendo-crinology, 2000, 72(2):114-125.
[25] Fluttert M, Dalm S, Oitzl M S.A refined method for sequential blood sampling by tail incision in rats[J]. Lab Anim, 2000, 34(4):372-378.
[26] Van Herck H, Baumans V, Brandt C, et al.Orbital sinus blood sampling in rats as performed by different animal technicians: the influence of technique and expertise[J]. Lab Anim, 1998, 32(4):377-386.
[27] Brown AP, Dinger N, Levine BS.Stress produced by gavage administration in the rat[J].Lab Anim Sci, 2000, 39(1):17-21.
[28] Gärtner K, Büttner D, D?hler K, et al. Stress response of rats to handling and experimental procedures[J]. Lab Anim, 1980, 14(3):267-274.
[29] Barrett AM, Stockham MA.The effect of housing conditions and simple experimental procedures upon the corticosterone level in the plasma of rats[J]. J Endocrinol, 1963, 26(1):97-105.
[30] 杨斐, 胡樱. 短途运输应激对 Wistar 大鼠的影响[J]. 中国实验动物学报, 2009, 17(4):279-283.
[31] Anderson D, Buckwell AC, Harris T, et al.Guidance on the transport of laboratory animals[J]. Lab Anim, 2005:39.
[32] Spencer SJ, Xu L, Clarke MA, et al.Ghrelin regulates the hypothalamic-pituitary-adrenal axis and restricts anxiety after acute stress[J]. Biol psychiat, 2012, 72(6):457-465.
[33] 翟亚南, 陈柏安, 郭萌, 等. 束缚应激的研究进展[J]. 实验动物科学, 2013, 30(4).
[34] 吴剑平. 不同常规实验操作和饲育环境对 Wistar 大鼠的影响[D]. 复旦大学, 2011:28-35
[35] Reinhardt V.Common husbandry-related variables in biomedical research with animals[J]. Lab Anim,2004,38:213-235.