Abstract: Enterovirus 71 (EV71) mainly infects humans through the gastrointestinal or respiratory tracts, which is one of the main pathogens of hand, foot and mouth disease. It can also cause neurological diseases such as neurogenic pulmonary edema and even death, threatening the safety of infants and young children. Although the whole-virus inactivated vaccine of EV71 has been marketed, the pathogenesis and immune response of complications caused by its infection have not been fully clarified. This article reviews the pathogenesis, immune response and immunogenicity response of EV71, which will pave the way for further research on EV71. 

Key words: Enterovirus 71, Pathogenesis, Animal experiment, Immune response