Abstract: As an excellent animal model, zebrafish (Danio rerio) has been widely used in the fields of developmental biology, genetics, toxicology and so on. Because it is great similar to human in aspect of eye morphology, anatomical structure, gene expression and function, and has advantages on rapid development, sperm reception way, embryo transparency and easy observation, zebrafish has been increasingly used in the study of eye development and related diseases such as eye defect, glaucoma, cataract, rod cone degeneration amd diabetic retinopathy. This article will review the eye development and structure of zebrafish as well as the advantages and disadvantages of zebrafish as a model for the study of eye diseases, which will help to have a more comprehensive understanding of the application value of zebrafish in the research of human eye diseases.

Key words: Zebrafish, Eye development, Eye diseases, Animal model