Laboratory Animal and Comparative Medicine ›› 2026, Vol. 46 ›› Issue (1): 149-152.DOI: 10.12300/j.issn.1674-5817.2025.213
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Received:2025-12-18
Revised:2026-01-03
Online:2026-02-25
Published:2026-02-14
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URL: https://www.slarc.org.cn/dwyx/EN/10.12300/j.issn.1674-5817.2025.213
| [1] | 孙强. 无替代,何谈取消[J]. 实验动物与比较医学, 2025, 45(3): 376-378. DOI: 10.12300/j.issn.1674-5817.2025.064 . |
| [2] | 孙强. 非动物实验替代知多少[J]. 实验动物与比较医学, 2025, 45(4): 508-513. DOI: 10.12300/j.issn.1674-5817.2025.117 . |
| [3] | 孙强. 中国实验猴产业的历史、现状、挑战与机遇[J]. 实验动物与比较医学, 2024, 44(4): 343-356. DOI: 10.12300/j.issn.1674-5817.2024.112 . |
| [4] | SCHÜRCH C M. Therapeutic antibodies for myeloid neoplasms-current developments and future directions[J]. Front Oncol, 2018, 18(8): 152. DOI: 10.3389/fonc.2018.00152 . |
| [5] | ADASHI E Y, O'MAHONY D P, COHEN I G. The FDA modernization act 2.0: drug testing in animals is rendered optional[J]. Am J Med, 2023, 136(9): 853-854. DOI: 10.1016/j.amjmed.2023.03.033 . |
| [6] | FDA. FDA announces plan to phase out animal testing requirement for monoclonal antibodies and other drugs[EB/OL]. (2025-04-10)[2025-09-15]. . |
| [7] | EFFER B, PEREZ I, ULLOA D, et al. Therapeutic targets of monoclonal antibodies used in the treatment of cancer: current and emerging[J]. Biomedicines, 2023, 11(7): 2086. DOI: 10.3390/biomedicines11072086 . |
| [8] | LEUNG C, JESSEN B, RATTEL B, et al. Considerations of non-human primate use in nonclinical toxicity study package for oncology therapeutics with well-characterized target in supports of 3Rs - an IQ DruSafe industry survey[J]. Regul Toxicol Pharmacol, 2025, 162: 105902. DOI: 10.1016/j.yrtph. 2025.105902 . |
| [9] | CHIEN H T, PRIOR H, ANDREWS L, et al. Re-evaluating the need for chronic toxicity studies with therapeutic monoclonal antibodies, using a weight of evidence approach[J]. Regul Toxicol Pharmacol, 2023, 138: 105329. DOI: 10.1016/j.yrtph.2022.105329 . |
| [10] | RALSTON S L, LI L, LEE D, et al. Strategies to reduce the use of non-human primates in development of oncology ADCs with cytotoxic payloads[J]. Regul Toxicol Pharmacol, 2025, 162: 105887. DOI: 10.1016/j.yrtph.2025.105887 . |
| [11] | KHONGORZUL P, LING C J, KHAN F U, et al. Antibody-drug conjugates: a comprehensive review[J]. Mol Cancer Res, 2020, 18(1): 3-19. DOI: 10.1158/1541-7786.MCR-19-0582 . |
| [12] | RICCARDI F, BO M DAL, MACOR P, et al. A comprehensive overview on antibody-drug conjugates: from the conceptualization to cancer therapy[J]. Front Pharmacol, 2023, 14: 1274088. DOI: 10.3389/fphar.2023.1274088 . |
| [13] | DRAGO J Z, MODI S, CHANDARLAPATY S. Unlocking the potential of antibody-drug conjugates for cancer therapy[J]. Nat Rev Clin Oncol, 2021, 18(6): 327-344. DOI: 10.1038/s41571-021-00470-8 . |
| [14] | CONNORS J M, JURCZAK W, STRAUS D J, et al. Brentuximab vedotin with chemotherapy for stage Ⅲ or Ⅳ Hodgkin's lymphoma[J]. N Engl J Med, 2018, 378(4): 331-344. DOI: 10.1056/nejmoa1708984 . |
| [15] | COLOMBO R, RICH J R. The therapeutic window of antibody drug conjugates: a dogma in need of revision[J]. Cancer Cell, 2022, 40(11): 1255-1263. DOI: 10.1016/j.ccell.2022.09.016 . |
| [16] | NEFF-LAFORD H D, CARRATT S A, CAROSINO C, et al. The vedotin antibody-drug conjugate payload drives platform-based nonclinical safety and pharmacokinetic profiles[J]. Mol Cancer Ther, 2024, 23(10): 1483-1493. DOI: 10.1158/1535-7163.mct-24-0087 . |
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