Abstract: Objective To explore the pathogenic mechanism of multiple system organ failure (MSOF) caused by extracranial tissue injury. Methods A Macaca thibetanas dead by extracranial tissue injury was pathologically examed. Results Gross pathology shows that there is swelling in the liver;atrophy of lung; hemorrhage and necrosis in subcutaneous tissue of head; edema in oxter lymph node and mesenterium lymph node. Histopathological examination shows that there is edema, degeneration and necrosis in many organs. The pathological changes of heart, lung, liver, kidney, intestine and brain is very distinct. Conclusion Extracranial tissue injury can cause many organ failure in Macaca speciose thibetanasare.

Key words: Macaca thibetana, Multiple system organ failure, Pathology