PI3K/Akt and AMPK Signaling Pathway and Effect of Exercise on Rodent Skeletal Muscle GLUT4 Translocation and Expression

doi:10.3969/j.issn.1674-5817.2017.01.017

Abstract

Abstract: Skeletal muscles play an important role in glucose homeostasis. The translocation and expression changes of glucose transporter 4 (GLUT4) as one of the most important glucose transporter proteins in skeletal muscle are closely associated with insulin resistance. This paper reviewed the recent research progress on the exercise-induced translocation and expression of GLUT4 as well as the improvement of exercise-induced glucose uptake by phosphatidylinositol 3-kinases (PI3K) / protein kinase B (Akt) and AMP-activated protein kinase (AMPK) signaling pathways in rodent skeletal muscle. The purpose of this paper is to clearly understand the mechanism underlying GLUT4 translocation and expression in rodent skeletal muscles.

Key words: Skeletal muscle, Exercise, Insulin resistance, Glucose transporter 4 (GLUT4), Phosphatidylinositol 3-kinases (PI3K), Protein kinase B (Akt), AMP-activated protein kinase (AMPK)

CLC Number:

Q95-33

ZHANG Yun-li, WANG Lin, LIU Tie-min. PI3K/Akt and AMPK Signaling Pathway and Effect of Exercise on Rodent Skeletal Muscle GLUT4 Translocation and Expression[J]. Laboratory Animal and Comparative Medicine, 2017, 37(1): 76-82.

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