Abstract: Any institution which cares and uses laboratory animals must comply with national and local regulations and standards by enhancing management and compliance. The institutions always attempt to minimize the risks of non-compliance when they establish the “laboratory animal care and use program”, this would accelerate the development and standardization of the global and local industry of laboratory animal science, on the other hand, the program often leads to redundant and superficial, the costs and budget of the program will increase dramatically, and finally it results in “self-imposed regulatory burden”. In this article, we will discuss about the major resources of “self-imposed regulatory burden”, how to evaluate “self-imposed regulatory burden” in the institution, and how to avoid “self-imposed regulatory burden”. At the end, we expect that the domestic institutions could make these as a guide, to understand, evaluate and balance their own managing goals and capabilities, to avoid the “self-imposed regulatory burden” at all.

Key words: Laboratory animals, Laboratory animal care and use program, Self-imposed regulatory burden