Analysis of Institutional Characteristics and Implementation of Guangdong Province Laboratory Animals Ordinance in the Past Decade

doi:10.12300/j.issn.1674-5817.2024.030

Abstract

Abstract:

The Guangdong Province Laboratory Animals Ordinance (the GPLAO), officially enacted and implemented in October 2010, marked a new phase of legal management in the administration of laboratory animals in Guangdong Province. The GPLAO clearly authorizes the laboratory animal monitoring institutes in Guangdong Province to conduct laboratory animal quality monitoring and assume corresponding legal responsibilities. It also specifies the standards for the production and use of laboratory animals, while bringing attention to laboratory animal welfare and ethics. Through the formulation of supporting documents, the active promotion of the standardization and regulation of administrative law enforcement, and the implementation of measures to delegate power, streamline administration, and optimize government services, significant improvements have been made in the standardized management of laboratory animals in Guangdong Province and in supporting the innovative development of biomedicine. Moreover, notable achievements have been made in areas such as the construction of experimental animal technology platforms, standardization work, the preservation and development of unique resources, and talent pool development. However, with the advancements in science and technology, social economy, and legislative work, some aspects in the GPLAO have been identified for improvement. These include the need for clearer provisions on laboratory animal welfare, more specific guidelines for the management of genetically engineered animals, improved regulations on the safety and welfare of practitioners, further refined implementation of the "one-vote veto system", continued promotion of laboratory animal standardization, and the exploration of effective mechanisms for resource sharing. This paper reviews and summarizes the institutional characteristics, post-legislation implementation, and effectiveness of the GPLAO, as well as the issues and countermeasures identified during the implementation. It concludes the laboratory animals management practices in Guangdong Province during the past 10 years, aiming to provide a reference for laboratory animal legislation.

Key words: Guangdong Province, Laboratory animals, Legal construction, Implementation

CLC Number:

Q95-33

DENG Shaochang,LIN Danrong,LIANG Chujun,et al. Analysis of Institutional Characteristics and Implementation of Guangdong Province Laboratory Animals Ordinance in the Past Decade[J]. Laboratory Animal and Comparative Medicine, 2024, 44(4): 455-462. DOI: 10.12300/j.issn.1674-5817.2024.030.

Figures/Tables 2

References 14

1	李中铎. 广东实验动物科技发展十年[M]. 广州: 广东科技出版社, 2003.
	LI Z D. Ten years of development in Guangdong laboratory animal science and technology [M]. Guangzhou: Guangdong Science and Technology Press, 2003.
2	李彪, 余亮, 陈梅丽, 等. 广东省实验动物许可证管理工作的现状及对策[J]. 中国比较医学杂志, 2014, 24(6):73-77. DOI: 10.3969/j.issn.1671.7856.2014.006.016 .
	LI B, YU L, CHEN M L, et al. Present situation and strategy of laboratory animal license management in Guangdong Province[J]. Chin J Comp Med, 2014, 24(6):73-77. DOI: 10.3969/j.issn.1671.7856.2014.006.016 .
3	巩和凌子, 孔琪, 刘江宁. 国内外实验动物法制化管理现状比较[J]. 中国比较医学杂志, 2020, 30(9):71-75. DOI: 10.3969/j.issn.1671-7856.2020.09.013 .
	GONG H L Z, KONG Q, LIU J N. Comparison of legal systems in China and abroad for improved management of laboratory animals[J]. Chin J Comp Med, 2020, 30(9):71-75. DOI: 10.3969/j.issn.1671-7856.2020.09.013 .
4	广东省人民政府. 广东省实验动物管理条例[A/OL]. [2024-04-12]. https://www.gd.gov.cn/zwgk/wjk/zcfgk/content/post_2524545.html.
	The People's Government of Guangdong Province. Regulations of Guangdong Province on the administration of laboratory animals[A/OL]. [2024-04-12]. https://www.gd.gov.cn/zwgk/wjk/zcfgk/content/post_2524545.html.
5	北京市人民代表大会常务委员会. 北京市实验动物管理条例[A/OL]. [2024-04-12]. https://www.beijing.gov.cn/zhengce/dfxfg/202107/t20210731_2453284.html.
	Standing Committee of Beijing Municipal People's Congress. Regulations of Beijing Municipality on the administration of laboratory animals[A/OL]. [2024-04-12]. https://www.beijing.gov.cn/zhengce/dfxfg/202107/t20210731_2453284.html.
6	湖北省人民代表大会常务委员会. 湖北省实验动物管理条例[A/OL]. [2024-04-12]. http://119.36.213.154:8088/fgk/index_xq.jsp?Rileid=787.
	Standing Committee of Hubei Provincial People's Congress. Regulations of Hubei Province on the administration of laboratory animals (2022 Revision)[A/OL]. [2024-04-12]. http://119.36.213.154:8088/fgk/index_xq.jsp?Rileid=787.
7	云南省人民代表大会常务委员会. 云南省实验动物管理条例[A/OL]. [2024-04-12]. https://kjt.yn.gov.cn/html/2007/qitawenjian_1024/849.html.
	Standing Committee of Yunnan Provincial People's Congress. Regulations of Yunnan Province on the administration of laboratory animals[A/OL]. [2024-04-12]. https://kjt.yn.gov.cn/html/2007/qitawenjian_1024/849.html.
8	黑龙江省人民代表大会常务委员会. 黑龙江省实验动物管理条例[A/OL]. [2024-04-12]. https://www.hljrd.gov.cn/content.html?id=3855.
	Standing Committee of Heilongjiang Provincial People's Congress. Regulations of Heilongjiang Province on the administration of laboratory animals[A/OL]. [2024-04-12]. https://www.hljrd.gov.cn/content.html?id=3855.
9	林丹荣, 何坚, 李文德, 等. 广东省实验动物资源现状调查及分析[J]. 中国比较医学杂志, 2018, 28(2):119-123. DOI: 10.3969.j.issn.1671-7856.2018.02.021 .
	LIN D R, HE J, LI W D, et al. An investigation of laboratory animal resources in Guangdong Province[J]. Chin J Comp Med, 2018, 28(2):119-123. DOI: 10.3969.j.issn.1671-7856.2018.02.021 .
10	贺争鸣, 李根平, 徐平, 等. 写在«实验动物管理条例»发布实施三十周年[J]. 实验动物科学, 2018, 35(4):1-13. DOI: 10.3969/j.issn.1006-6179.2018.04.001 .
	HE Z M, LI G P, XU P, et al. Written on the 30th anniversary of the promulgation and implementation of the regulations for the administration of laboratory animals[J]. Lab Anim Sci, 2018, 35(4):1-13. DOI: 10.3969/j.issn.1006-6179.2018.04.001 .
11	贺争鸣, 李根平, 陈梅丽, 等. 实验动物地方标准的查新和确认机制的建立及地方标准的应用[J]. 实验动物科学, 2017, 34(2):44-50. DOI: 10.3969/j.issn.1006-6179.2017.02.010 .
	HE Z M, LI G P, CHEN M L, et al. Establishment of novelty searching and verification system for the local standards of laboratory animals and application of these standards[J]. Lab Anim Sci, 2017, 34(2):44-50. DOI: 10.3969/j.issn.1006-6179.2017.02.010 .
12	艾曼, 陈林, 漆重阳, 等. 江苏省实验动物标准体系研究[J]. 中国标准化, 2021(24):78-83. DOI: 10.3969/j.issn.1002-5944.2021.24.012 .
	AI M, CHEN L, QI C Y, et al. Research on the standard system of laboratory animal in Jiangsu Province[J]. China Stand, 2021(24):78-83. DOI: 10.3969/j.issn.1002-5944.2021.24.012 .
13	孔琪, 李继平, 赵永坤. 实验动物资源是生物医药产业创新的重要支撑条件[J]. 科技导报, 2016, 34(11):12-13. DOI：CNKI:SUN:KJDB.0.2016-11-009 .
	KONG Q, LI J P, ZHAO Y K. Experimental animal resources are an important supporting condition for the innovation of biomedical industry[J]. Sci Technol Rev, 2016, 34(11):12-13. DOI：CNKI:SUN:KJDB.0.2016-11-009 .
14	贺争鸣. 基于能力提升的我国实验动物资源发展愿景[J]. 实验动物与比较医学, 2021, 41(2):85-90. DOI: 10.12300/j.issn.1674-5817.2021.042 .
	HE Z M. Development vision of laboratory animal resources in China based on ability improvement[J]. Lab Anim Comp Med, 2021, 41(2):85-90. DOI: 10.12300/j.issn.1674-5817.2021.042 .

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