Abstract: Objective To establish a comparative histology database of commonly used laboratory animals. Methods All the main organs and tissues from 6 species of laboratory animals, the mouse, rat, rabbit, guinea pig, dog and cynomolgus monkey, were collected. After embedded by paraffin, sectioned and stained with hematoxylin and eosin, tissue sections were observed under microscope and described. The comparative pathology database were established by SQL Server 2008 database management system. Results Tissues were compared among these 6 species of laboratory animals and distinctive pictures were got plused with descriptions. A user-friendly, inquiry conveniently and shared comparative histology database were established. Conclusion The establishment of comparative histology database are benefit for research of animal pathology and disease model in the field of bio-medicine.

Key words: Laboratory animal, Comparative histology, Database