Abstract: Objective To observe the degree of injuries in rabbit gastric mucosal induced by different doses of anhydrous ethanol. Methods Twenty-eight New Zealand White rabbits were randomly divided into A, B, C, D groups (n=7). Group A was control group. The anhydrous ethanol 2.35 ml/kg , 1.00 ml/kg, 0.50 ml/kg with the dossage of were taken by intragastric administration to induce gastric mucosal lesion in group B, C, D respectively . The degree of gastric mucosal lesion was assessed by general morphology, biopsy and general physical condition. Results Compared with A group, gastric mucosal lesions were observed in the other three groups.Through general morphology of gastric, gastric ulcers were observed in group B, hyperemia, edema and erosion of gastric mucosal were observed in group C, but no significant lesion was observed in group D. Through biopsy, the lesions in group B were observed in muscle, mucosa in group C and nucosa epithelial in group D. Conclusion Anhydrous ethanol can induce gastric mucosal lesion models, 2.35ml/kg can induce gastric ulcer model, 1.00 ml/kg can induce gastric mucosal lesion model of erosion and hemorrhage, and 0.5ml/kg dosage did not show significant effects on gastric lesion.

Key words: Different doses, Anhydrous Ethanol, Rabbits, Gastric mucosal lesion