Abstract: Objective To investigate the changes of the content of calcium, phosphorus and zinc in serum and the morphology of skeleton in the development of stress fracture in rabbits. Methods Sixty male rabbits were randomly divided into control group(n=30) and experimental group(n=30). Let the experiment rabbits run and jump for 300 times per day with high voltage and under-current stimulation, 6 times a week ,and totally 5 weeks.Six rabbits each group were sacrificed every week for the determination of the content of calcium, phosphorus and zinc in serum and tissue, for determination of the content of parathyroid hormone, osteocalcin and calcitonin in serum, and for observing the pathological changes of tibia. Results The injury of tibia tissue was exacerbated as training time increased. The serum zinc from experimental group was significantly higher than that of the control group(P<0.05) after 3 weeks training. The content of parathyroid hormone, osteocalcin and calcitonin in serum showed no difference between experimental and control group. Conclusions The element of calcium and zinc might play some roles in the development of the experimental stress fracture.

Key words: Rabbits, Stress Fracture, Tibia Morphology, Biochemical Indices