Abstract: Objective To investigate the influences of high fat diet and low androgen level on structure of penis and expression of COX-2 in penis of the rat. Methods Adult male SD rats in ten weeks old were randomly divided into six groups: normal diet group, normal diet and castrated group, normal diet and castrated with undecanoate replenishment group, high fat diet group, high-fat diet and castrated group, high-fat diet and castrated with undecanoate replenishment group . After 10 weeks, the androgen level ,,structure of penis and expression of cyclooxygenase-2 (COX-2) in corpora cavernosa of penis in these six groups were observed. Result The level of androgen in castration groups was decreased obviously,but the undecanoate replenishment can elevate the level. In high-fat diet group, structure of penis was damaged and COX-2 expression was positive in vascular of penile corpora cavernosa. Conclusion Castration operation could establish the low androgen model in male SD rats, and which could induce the damage of penis. The positive expression of COX-2 in high fat diet rats was implied that inflammatory path way was excited by high fat diet in low androgen male rats.

Key words: Castration operation, High fat diet, Androgen, COX-2