关键词: 子宫腺肌病, 激动剂, 拮抗剂, 内膜容受性

Abstract: Objective To compare the effect of GnRH analogues on endometrium receptivity of adenomyosis mouse model induced by tamoxifen. Methods The mouse model of adomyosis was made through Oral administration of \tamoxifen.when adenomyosis was established, mice were randomly divided into three groups and were intraperitoneally injected with normal saline, triptorelin, cetrorelix respectively; there were another two groups of normal mice injected with triptorelin,cetrorelix. After injection, the mice werre mated with the male ones, Then each group mice was divided into two parts, one part would be collected uterus in implant window, and another would be euthanized to calculate the number of embryo on E13.5 d. Result The endometrium receptivity (HOXA10, integrin β3)of the adenomyosis mouse model was decreased and there werre no embryo implanted, and in cetrorelix group,there was no significantly change. But in triptorelin group, endometrium receptivity was increased and the number of embryo was 23. However, triptorelin could not improve the endometrium receptivity. of normal mice. Conclusion Triptorelin can improve the endometrium receptivity of adenomyosis mice model but not for normal mice, and cetrorelix can not increase endometrium receptiveity.

Key words: Adenomyosis, GnRH agonist, GnRH antagonist, Endometrium receptivity