国衡颈通部分药效学作用研究

实验动物与比较医学 ›› 2010, Vol. 30 ›› Issue (5): 372-376.

国衡颈通部分药效学作用研究

1.上海医药工业研究院药理室，上海，200040；2.上海方心科技研究所，上海，200032

收稿日期:2010-03-29 出版日期:2010-05-31 发布日期:2010-05-31

Research on Pharmacodynamic Action of Guo Heng Extract

1.Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China;2.Shanghai Fangxin Technology Institute, Shanghai 200032, China

Received:2010-03-29 Published:2010-05-31 Online:2010-05-31

摘要/Abstract

摘要： 目的观察国衡颈通浸膏不同剂量抗炎、镇痛、活血化瘀及抗软组织损伤的作用。方法采用二甲苯致小鼠耳廓肿胀，角叉菜胶致大鼠足跖肿胀、醋酸致小鼠扭体疼痛、大鼠皮肤创伤性瘀斑及软组织急性损伤模型，观察药物作用。结果国衡颈通能抑制由二甲苯所致的小鼠耳廓肿胀和角叉菜胶所致大鼠足跖肿胀，减轻醋酸所致的小鼠扭体疼痛，治疗大鼠皮肤创伤性瘀斑和软组织损伤。结论国衡颈通具有抗炎、镇痛、活血化瘀及抗软组织损伤作用。

关键词: 国衡颈通浸膏, 抗炎, 镇痛, 活血化瘀, 软组织损伤

Abstract: Objective To observe the function of anti-inflammation, abirritation, activating blood circulation and alleviating soft tissue injuries of “Guo heng extract”. Methods The ear swelling of mouse induced by xylene, foot edema caused by carrageenan, the pain reaction of mouse by chemical stimulation, traumatic skin ccchymosis of rat and acute soft tissue injury model were adopted to investigate the treatment effects of the drug. Result The three dosage groups displayed significantly anti-inflam-mation and the analgesia function to ear swelling and foot edema of mouse, and writhing response mouse stimulated by acetic acid. The middle and high dosage groups could promote blood circulation and mitigate soft tissue injuries. Conclusion “Guo heng extract” had obvious anti-inflammation and the analgesia function. It also had the inhibitory action to skin ecchymosis and soft tissue injuries, and showed some dose-effect relationship.

Key words: Guo heng extract, Anti-inflammation, Analgesia;Blood circulation, Soft tissue injuries

沈龙海1,安泳潼1,孟庆涛2,等. 国衡颈通部分药效学作用研究[J]. 实验动物与比较医学, 2010, 30(5): 372-376.

SHEN Long-Hai-1,AN Yong-Tong-1,MENG Qing-Tao-2,et al. Research on Pharmacodynamic Action of Guo Heng Extract[J]. Laboratory Animal and Comparative Medicine, 2010, 30(5): 372-376.

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