实验动物与比较医学 ›› 2007, Vol. 27 ›› Issue (4): 276-279.

• 论文 •    

鼠诺沃克病毒特征及其检测技术

  

  1. 北京实验动物研究中心,北京 100012

Structural Character and Detective Techniques of Murine Norovirus

  1. Beijing Laboratory Animal Research Center, Beijing 100012,China

摘要: 鼠诺沃克病毒-1(MNV-1)是一个新认知的鼠病原体,可引起固有免疫系统应答组分缺陷鼠的致死性感染,是目前唯一一个能够在细胞以及小动物体中复制的诺沃克病毒.通过病毒分离、免疫组化、RT-PCR技术,均可检测鼠诺沃克病毒-1.

Abstract: Murine Norovirus l(MNV-l) is a newly recognized pathogen of mice that causes lethal infection in mice deficient in components of the innate immune response. Moreover, the murine virus 1 is the only norovirus that can replicate in cell culture and in a small animal. Murine norovirus 1 is detected by virus isolation, immunohistochemistry method and RT-PCR technique.