关键词: 扩张型心肌病, 心力衰竭, 新西兰兔, 动物模型, ^99mTc-MIBI

Abstract: Objective To establish Adriamycin-induced dilated cardiomyopathic(DCM) model through ear-border vein in New Zealand rabbit, and the model were evaluted by light microscopy,electron microscopy,myocardial perfusion imaging and indexes of hemodynamics. Methods Twenty male New Zealand rabbits were randomly divided into model group and control group equally. Adriamycin was injected to produce DCM model through ear-border vein. Indexes of hemodynamics were measured to evalute the cardiac function.^99mTc-MIBI myocardial perfusion imaging showed the difference between control group and model group.Histomorphological changes were evaluted by light microscopy and ultrastructure characteristics were investigated by transmission electron microscopy. Results Cardiac examinations indicated there was statistical significance compared with control group. Myocardial perfusion imaging indicated low infusion in cardiac apex, ventricular cavity became enlarged and the wall was thin.The histomophological and ultrastructure changes of myocardium coincide with the characteristics of DCM. Conclusions The adriamycin-induced cardiomyopathic rabbit model was similar to the histo-pathological changes of DCM in humans,it may be used for stem cell basic research in cardiology.

Key words: dilated cardiomyopathy, heart failure, New Zealand rabbits, animal model, ^99mTc-MIBI