血管性痴呆是由于一系列脑血管因素引起的脑组织血液循环障碍、脑部机能减退而致的一种认知功能缺损的综合征。建立合适的脑缺血所致VD动物模型对于深入探讨VD的发病机制、病理学特点以及临床患者的早期诊断、早期治疗甚至早期预防均有重要意义。本文对VD的动物实验模型研究进展做一综述。

Vascular dementia （VD） is a syndrome manifested by declines in cognitive function which is the results of cerebral blood flow disorders and functional disorders caused by a series of cerebral vascular factors. It is of vital importance to establish a VD animal model caused by cerebral ischemia to deeply explore the etiology, pathological features of the disease and to insure an early diagnosis, treatment and even prevention for the patients. In this study, a review was performed in the research progress of experimental VD animal model.