Abstract: To establish the allergic asthma model, guinea pigs were intraperitoneally injected with ovabulmin, and challenged by inhaling ovabulmin with ultrasonically nebulised inhaler two weeks later. The total number of cell and eosinphil count in brochial alveolar lavage fluid （BALF）, eosinphil count in plasma, airway resistance,pathology were detected. The results showed that eosinphil count in plasma and BALF of the model animal were significantly increased after the challenge compared with the control, intrapul-monary pressure were increased after inhaling histamine, and eosinphil imflammion were found in patho-logical exanination.