Abstract: To investigate the weight-reducing effect of methyl cellulose M450 on aged ovariectomized （OVX ） rats，the cellulose was administered intragastrically to ten-month old rats that were ovariectomized in six-month for 30 days, the body weight, weight of celiac fat tissue,adipocytc number,adipocyte size,blood lipid and cholesterol were observed. The results showed that the body weight,weight of celiac fat tissue,adipocyte size in the rats of 100 mg/kg and 200 mg/kg cellulose groups were significantly lower than those in control group （P＜0. 05）； and the level of blood lipid and cholesterol were lower too in the 200 mg/kg group （P＜0.05）；the results suggested that administration of cellulose （＞100 mg/kg） to rats for 30 days have evident weight-reducing effect and can also decrease the blood lipid level, but 30 mg/kg cellulose group have no effect at all （P＞0.05）.