Abstract: Cirrhosis model （CM） of animal was the base for cirrhosis, portal hypertension and hepatocarcinoma research in human. Monofactor method was generally used to make CM of specific etiological factor. Multiple factors method was used to increase success rate, reduce time consuming and death rate. The problem at present were no CM of hepatitis , fewer reports on large animals , harmful inducers to researchers，low successful rate and high death rate.