实验动物与比较医学 ›› 2002, Vol. 22 ›› Issue (1): 10-12.
• 论文 •
摘要： 为探讨大鼠标准胫骨骨折模型的制作，首先将62只雌性SD大鼠的双侧胫骨髓腔插入9mm直径的医用克氏针，然后通过自行设计制作的骨折造模支架造成胫骨中段闭合骨折，术后通过X线、组织学检查了解骨折类型、移位程度以及骨折的愈合情况。结果术后X线证实横断或短斜型骨折，移位不明显的92例，占总例数的74.2%。组织学检查骨折呈典型的二期愈合过程。通过自制骨折造模支架制作的大鼠胫骨横断骨折模型重复性好，外在因素对骨折的影响小，制作简便，符合标准骨折模型的要求。
Abstract: To explore the development of a standard closed fracture in rat tibia, a modi-fied apparatus was designed and tested on 62 female SD rats. The tibia was treated with an intramedullary Steinmann’s pin and then was fractured by the apparatus. The frac-ture type and displacement was observed by X-ray and the fracture healing was detected histologically. The fractures were transverse or transverse with a small oblique compo-nent in 92 cases with the success rate 74.2%. Histologically the fracture was healed in secondary. The closed fracture model of rat tibia made by the apparatus is highly repro-ducible,easy to make，and is a standard model.
. Development of a Standard Closed Fracture in Rat Tibia[J]. Laboratory Animal and Comparative Medicine, 2002, 22(1): 10-12.
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