化学性血管再狭窄大鼠模型的建立

›› 2001, Vol. 21 ›› Issue (4): 215-216.

化学性血管再狭窄大鼠模型的建立

上海医药工业研究院药理研究室,上海 200437

收稿日期:2001-03-05 出版日期:2001-01-25 发布日期:2013-03-19

Carotid Artery Stenosis Model Induced by FeCl₃ in Rat

Department of Pharmacology, Shanghai Institute of PharmaceuticaL Industry，Shanghai 2004379,China

Received:2001-03-05 Online:2001-01-25 Published:2013-03-19

摘要/Abstract

摘要： 为了开展对平滑肌增生引起血管狭窄的实验研究，用化学方法损伤内皮细胞建立血管平滑肌增生模型。方法是利用不同浓度三氯化铁和改变作用时间，造成不同程度的血管内皮损伤，使平滑肌细胞从中膜迁移到内膜增生形成动脉狭窄，其病理变化和气囊插管法相似，操作容易，可定量控制损伤程度，个体间差异较小，适于大规模药效试验和新药筛选。

关键词: 基因治疗, 血管再狭窄, 经皮冠状动脉腔内成形术

Abstract: We constructed an experimental rat carotid artery stenosis model induced by FeCl₃. The smooth muscle cells migrate from the median to form a neointimal after the endothelial cells are injured by FeCl₃. The FeCl<sub>3</sub> injury model has the same pathology as balloon injury model, and easier to operating, and also the degree of injury can be controlled quantotatively. It will be useful in screening new drugs and pharmacodynamic study.

Key words: Gene therapy, Restenosis, PCTA

闵晹，陆晴，刘全海. 化学性血管再狭窄大鼠模型的建立[J]. , 2001, 21(4): 215-216.

MIN Yang, LU Qin, LIU Quan-hai. Carotid Artery Stenosis Model Induced by FeCl₃ in Rat[J]. , 2001, 21(4): 215-216.

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