›› 2001, Vol. 21 ›› Issue (3): 181-185.

• 论文 • 上一篇    下一篇

非手术制备先天性心脏病动物模型的研究进展

  

  1. 四川大学华西医学中心附二院儿科,成都 610041
  • 出版日期:2001-01-25 发布日期:2013-03-19

Progress in Animal Models of Congenital Heart Diseases by Non-surgery Screening

  1. Pediatrics,the Second Affiliated Hospital,West China Medical Center,Sichuan University, Chengdu 610041,China
  • Online:2001-01-25 Published:2013-03-19

摘要: 小儿先天性心脏病研究领域中动物模型的制备非常困难,目前尚无公认的方法。本文从常用的两种建模方法中选择种群筛选法,综述了近年的研究进展,探讨了多种筛选方法在临床应用的前景,为深入开展先天性心脏病发病机制、病理生理变化及治疗的分子、基因水平研究提供基础。

关键词: 先天性心脏病, 动物模型

Abstract: Animal models of congenital heart diseases were difficult to produce and no reliable methods were recognized. The authors reviewed the recent progress in the models of congenital heart diseases made by non-surgery screening and discussed their clinical applications for research in etiology, patho-physiology and therapy at molecule and gene level.

Key words: Congenital heart diseases , Animal model