雄性兔膀胱出口部分梗阻动物模型的建立

›› 2001, Vol. 21 ›› Issue (3): 140-142.

雄性兔膀胱出口部分梗阻动物模型的建立

复旦大学附属中山医院1.泌尿外科；2.动物实验中心,上海 200032

收稿日期:2000-12-08 出版日期:2001-01-25 发布日期:2013-03-19

Establishment of Animal Model of Partial Bladder Outlet Obstruction in Male Rabbit

1.Department of Urology； 2.Animal Experimental Center, Zhongshan Hospital, Fudan University,Shanghai 200032,China

Received:2000-12-08 Online:2001-01-25 Published:2013-03-19

摘要/Abstract

摘要： 采用成年雄性新西兰白兔，应用膀胱颈部结扎的方法，制成膀胱出口部分梗阻动物模型模拟人类继发于良性前列腺增生（BPH）所引起的膀胱功能改变。在手术后5周测定实验兔膀胱重量、容量及其逼尿肌束的收缩性。结果发现梗阻组实验兔膀胱重量明显增加，容量明显减少，逼尿肌收缩性明显下降，它为研究人类继发于BPH的膀胱逼尿肌功能障碍的发生机制及探索对膀胱功能恢复的治疗提供有效的动物模型。

关键词: 膀胱出口梗阻, 逼尿肌, 收缩性

Abstract: To imitate the dysfunction of detrusor following benign prostatic hypertrophy in man，the bladder ncck of male rabbits were partial ligated. The weight、volumexde-trusor contractibility were measured 5 weeks after operation . The detected items were all changcd significantly in obstructed group. It may be used as an effective animal mod cl in studying the therapeutic methods for detrusor dysfunction following benign pro-static hypertrophy in man bccausc of its pathophysiological course mimicking BPH in man.

Key words: Bladder outlet obstruction , Detrusor, Conlraclibility

王杭1，王国民1，秦建琦2. 雄性兔膀胱出口部分梗阻动物模型的建立[J]. , 2001, 21(3): 140-142.

WANG Hang1, WANG Guo-min1, QIN Jian-qi. Establishment of Animal Model of Partial Bladder Outlet Obstruction in Male Rabbit[J]. , 2001, 21(3): 140-142.