Abstract: For establishing rat model of uric acid nephropathy(UAN), the rats were fed with yeast only, or yeast and adenine, or yeast and adenine and sardine respectively. The changes of serum uric acid(UA), creatinine (Scr), blood urea nitrogen (BUN) and renal tissue structure were examined after the model had been founded. Compared with that of the normal group rats, the processed rats presented substantially increasing of UA,Scr,BUN. It was found that the renal pathological change in the model rats induced by feeding with yeast only could imitate the manifestations of primary UAN in human, and the latter two models correspond to occurrence of mechanism of secondary UAN of human.