›› 2000, Vol. 20 ›› Issue (3): 129-132.

• 论文 •    下一篇

宫内乙醇暴露对新生大鼠脑唾液酸含量的影响

  

  1. 福建医科大学分子医学教研室,福州 350004
  • 收稿日期:2000-04-15 出版日期:2000-01-25 发布日期:2013-03-19

In Utero Ethanol Exposure Affects the Content of Sialic Acids in Newborn Rat Brain

  1. Department of Molecular Medicine,Fujian Medical University,Fuzhou 350004,China
  • Received:2000-04-15 Online:2000-01-25 Published:2013-03-19

摘要: 研究了宫内乙醇暴露对新生大鼠脑唾液酸含量及唾液酸酶活性的影响。Wistar母鼠在孕期的第7、8、13和14天暴露于乙醇(灌胃给予),对出生后3天(PD3)、5天(PD5)和10天(PD10)的新生大鼠测定其脑唾液酸含量和唾液酸酶活性。结果表明,仔鼠在PD3、PD5的脑唾液酸含量显著增加,而唾液酸酶的活性则无明显改变。

关键词: 宫内乙醇暴露, 唾液酸, 唾液酸酶活性

Abstract: We have investigated the effects of ethanol exposure in utero on the content of sialic acid and sialidase activity in newborn rat brain. Dams were exposed to ethanol in gestation days 7,8,13 and 14,the content of sialic acid were significantly increased in postnatal days 3 (PD3) and 5 (PD5) pups brain. No significant change was found on the sialidase activity.

Key words: In utero ethanol exposure, Sialic acid, Sialidase activity