实验动物与比较医学 ›› 1999, Vol. 19 ›› Issue (2): 96-96.

• 论文 •    

局灶性脑缺血大鼠模型的研究

  

  1. 1.第一军医大学实验动物学教研室;2.南方医院实验动物所,广州 510515

A Focal Cerebral Ischemia Model by Occluding Middle Cerebral Artery in Rat

摘要: 采用开颅电凝阻断大鼠一侧大脑中动脉并结扎同侧颈总动脉的方法,复制了局灶性脑缺血模型。应用神经检查分级评估法、组织化学染色和计算机图象处理系统,证实了该模型的可靠性。

Abstract: The single lateral middle cerebral arteries (MCA) of SD rats were occluded with electric heating coagulation following the ligation of ipsilaternl common carotid artery (CCA). After 7 clays,the focal cerebral ischemia in the animals were evaluated with a neurologic examination grading system,histochemistry staining techniques and a computer image analytic system. The results showed that focal cerebral ischemia model was duplicated . ancl was reliable and practical for the studies on brain infarction and its therapy.