用HBsAg特异性细胞毒性T淋巴细胞（CTL）给HBV转基因ICR小鼠过继性输注，通过肝组织病理学和免疫组化观察，发现其能诱发类似急性肝炎病变，提示抗原特异性CTL在HBV抗原所引起的宿主细胞免疫应答而导致肝细胞损伤的过程中有作用。

Three days after the HBsAg-specific cytotoxic T lymphocytes (CTL) were injected into the HBV transgenic mice，acute liver injury similar to human acute hepatitis was observed in CTL injected mice by histopathological and immunohistochemistry methods. The results indicate that HBsAg - specific CTL plays an important role in the liver injury triggered by host cell immunoresponse.