实验动物与比较医学 ›› 1997, Vol. 17 ›› Issue (4): 199-202.
• 论文 •
摘要： 采用直接吸入常压低氧（O2浓度为10%）和低氧伴高二氧化碳（O2浓度为10%，CO2浓度为6.5%）混合气体（每天8h，共4周）的方法制备肺动脉高压大鼠模型。观察实验大鼠的平均肺动脉压、平均右心室压、右心室重量及心脏和肺脏的病理学改变，并作血气分析。结果表明，实验大鼠可在较短时间内出现典型的肺动脉高压和右心室肥厚。
Abstract: Pulmonic hypertension in 2 groups of Wistar rats was induced by exposing the rats to an isobaric atmosphere containing 10% O2， and the other containing 10% O2 with 6.5% CO2 respectively for 8h daily for 4 weeks. The mean pulmonary arterial pressure and right ventricular pressure, right ventricular weight, blood gas analysis and pathological changs of the hearts and lungs in the rats were observed. The results showed that the pulmonic hypertension models could be established in a short time (4 weeks) ,and could mimic cor pulmonale with respiratory failure in human better than that induced by hypobaric hypoxia.
. Pulmonic Hypertension Induced by Chronic Isobaric Hypoxia and Hypoxia with High Concentration of C02 in Rats[J]. Laboratory Animal and Comparative Medicine, 1997, 17(4): 199-202.
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https://www.slarc.org.cn/dwyx/CN/Y1997/V17/I4/199
