›› 1996, Vol. 16 ›› Issue (2): 79-81.

• 论文 • 上一篇    下一篇

卵巢摘除对兔体内3种血清磷酸酶活性的影响

  

  1. 上海第二医科大学附属瑞金医院,上海市伤骨科研究所,上海 200025
  • 收稿日期:1995-10-25 修回日期:1996-03-13 出版日期:1996-02-25 发布日期:1996-02-25

Effects of Oophorectomy on Activities of Serum Alkaline Phosphatase,Acid Phosphatase and Bone - specific Alkaline Phosphatase in Rabbits

  1. Shanghai Institute of Traumatology and Orthopedics, Shanghai 200025
  • Received:1995-10-25 Revised:1996-03-13 Online:1996-02-25 Published:1996-02-25

摘要: 探讨绝经后妇女骨质疏松症与骨代谢有关酶活性变化的关系,测定了12只7月龄新西兰兔双侧卵巢摘除前与摘除后8个月的血清碱性磷酸酶、酸性磷酸酶和骨特异性碱性磷酸酶的活性。结果:术前这3种酶的活性分别为20.06±8.20、19.06±5.46和14.04±1.67U/L;术后8个月,分别为14.60±4.64、11.04±4.10和4.44±2.10U/L,均非常显著地低于术前(P<0.001)。骨特异性碱性磷酸酶的下降幅度比碱性磷酸酶大,说明以它作为骨代谢指标比碱性磷酸酶更灵敏。骨特异性碱性磷酸酶术后下降幅度也大于酸性磷酸酶。提示:这些酶的活性变化可能是绝经后妇女骨质疏松症的部分生化基础。

关键词: ", 兔, 卵巢摘除, 碱性磷酸酶, 酸性磷酸酶, 骨特异性碱性磷酸酶 "

Abstract: Twelve female New Zealand white rabbits of 7 months old were subjected to oophorectomy. Before the oophorectomy the activities of serum alkaline phosphatase,acid phosphatase and bone - specific alkaline phosphatase were 20.06±8.20,19.06±5.46 and 14.04±1.67U/L respectively and declined significantly to 14.60±4.64,11.04±4.10 and 4.44±2.10 U/L respectively 8 months after oophorectomy(P<0.001). Since the decline in bone -specific alkaline phosphatase activity far exceeded that in the alkaline phosphatase activity, the former could be used as a sensitive special index for bone metabolism. The decline in bone - specific alkaline phosphatase also exceeded that in the acid phosphatase activity. The results suggest that the activities of these enzymes can be considered as a part of the biochemical parameters for osteoporosis in postmenopausal women.

Key words: "Oophorectomy, Alkaline phosphatase, Acid phosphatase, Bone-specific alkaline phosphatase, Rabbit "