›› 1996, Vol. 16 ›› Issue (1): 8-10.

• 论文 • 上一篇    下一篇

大鼠刀伤后创面肉芽组织SOD、MDA、GSH和GSH-PX含量的变化

  

  1. 中国人民解放军304医院创伤中心研究室,北京 100037
  • 收稿日期:1994-11-08 出版日期:1996-01-25 发布日期:1996-01-25

Changes of SOD,MDA,GSH and GSH - PX Contents in Granulation Tissues of Resected Wounds in Rats

  1. Trauma Center, 304 Hospital of Chinese People’s Liberation Army, Beijing 100037
  • Received:1994-11-08 Online:1996-01-25 Published:1996-01-25

摘要: 为了解受创组织修复过程中氧化与抗氧化能力的变化,以酶学法测定了大鼠刀伤创面肉芽组织匀浆中超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-PX)的含量。伤后3、5、7d的SOD、GSH-PX含量呈“V”型改变,GSH呈“∧”型改变,MDA逐渐升高,伤后7d与3d的SOD及MDA比较,均呈显著性差异(P<0.05)。结果提示,创伤修复中局部组织存在脂质过氧化反应;组织中抗氧化酶含量的分布与修复质量有关;如果在愈合不同阶段应用外源性抗氧化剂,可能有利于创伤修复。

关键词: 创伤修复, 肉芽组织, 超氧化物歧化酶, 丙二醛

Abstract: The changes of superoxide dismutase (SOD) , malonyldialdehyde (MDA),glutathione (GSH) , and glutathione peroxidase (GSH - PX) contents in granulation tissues were observed in resected wounds of rats. The results revealed that the curve of SOD and GSH - PX changes was showed in "V "type,while in GSH was showed in " A "type,and MDA content increased gradually after resection. The contents of SOD and MDA were higher at day 7 than day 3(P<0.05). It was concluded that the changes of SOD,MDA,GSH and GSH-PX contents were present in the process of wound healing.

Key words: Wound healing, Granulation tissue, SOD, MDA, GSH, GSH-PX