›› 1996, Vol. 16 ›› Issue (1): 1-4.

• 论文 •    下一篇

甾体激素对豚鼠子宫内膜蜕膜化的影响

  

  1. 上海市计划生育科学研究所,上海 200032
  • 收稿日期:1995-07-03 出版日期:1996-01-25 发布日期:1996-01-25
  • 基金资助:

    国家自然科学基金资助

The Induction of Endometrial Decidual ization by Steroid Hormones in Guinea Pigs

  1. Shanghai Institute of Planned Parenthood Research, Shanghai 200032
  • Received:1995-07-03 Online:1996-01-25 Published:1996-01-25

摘要: 研究了孕激素、雌激素、抗孕激素和抗雌激素药物对豚鼠子宫内膜蜕膜形成和生长的调控。结果表明:子宫内膜蜕膜化和蜕膜组织的变化是受卵巢激素的调控,特点是在蜕膜化早期需要激素的作用,一旦起动,则不再依赖于激素的支持。RU486抗孕激素及克罗米芬(抗雌激素)的试验更进一步证明了激素对豚鼠内膜蜕膜化的作用。

关键词: 豚鼠, 蜕膜, 孕激素, 雌激素, RU486, 克罗米芬

Abstract: The ability of steroid hormones to modulate endometrial differentiation has been studied in guinea pigs. The purpose of the study was to determine the hormonal conditions favorable for supporting decidual I tissue formation and effects of progestin,antigestagen,estrogen and antiestrogen on uterine cell differentiation. The results indicated that the induction and extent of decidual formation were dependent on the progestin and estrogen. Estrogen is essential for supporting the progestin directed differentiation and proliferation of endometrium with the formation of decidual tissue in stimulated guinea pigs. The ability of decidual-ization occuring in the guinea pig only requires the endometrium be initially primed by these ovarian steroid hormones. The results also demonstrated that antigestagen RU486 and antiestrogen Clomiphene influence endometrium differentiation and decidual tissue formation.

Key words: "Guinea pig, Decidua, Progestin, Estrogen, RU486, Clomiphene "