›› 1995, Vol. 15 ›› Issue (2): 72-74.

• 论文 • 上一篇    下一篇

大鼠胃溃疡病的复制与自动修复过程观察

  

  1. 1.中国人民解放军304医院;2.中国人民解放军海军总医院
  • 收稿日期:1994-08-30 出版日期:1995-01-25 发布日期:2013-03-19

Duplication of Gastric Ulcer in Rats and Observation of Its Renovation

  1. 1.304 th Hospital, PLA, Beijing 100037;2.Naval General Hospital , PLA
  • Received:1994-08-30 Online:1995-01-25 Published:2013-03-19

摘要: 在成年Wistar大鼠胃粘膜下注射20%冰醋酸,复制胃溃疡模型。术后每隔1周处死大鼠10只,剖胃观察,连续4周。发现胃溃疡复制术后第1周至第2周,溃疡病态最典型,溃疡发生率为100%。从第3周起,溃疡自动修复过程加快,第3周末溃疡愈合率为60%,第4周末溃疡愈合率达90%,粘膜明显修复。本法复制的胃溃疡模型,其自愈速度与人类相近。

关键词: 实验性胃溃疡, 大鼠, 自动修复

Abstract: Gastric ulcer was duplicated in 40 Wistar rats by injection of 20% acetic acid under their gastric mucosae. Ten rats, stomaches were opened for observation every week after the injection. The results showed that the duplicated gastric ulcers were very typical and the incidence was as high as 100% within two weeks. The renovation of the ulcers was very fast during the 3 rd week, and by the end of the 3 rd week 4 cases of ulcer can be seen in 10 rats. At thw 4 th week there was only 1 case of ulcer in 10 rats, and the gastric mucosae were renovated markedly. The renovating course is similar to that of human gastr ulcers.

Key words: "Gastric ulcer, Duplication, Renovation, Rat "